Round 1
| Date | Venue | Time | |
| Thu 5 Aug 2010 | Melbourne Heart v Central Coast Mariners FC | AAMI Park | 7:30PM |
| Fri 6 Aug 2010 | Adelaide United FC v Newcastle Jets FC | Hindmarsh Stadium | 7:30PM |
| Fri 6 Aug 2010 | Perth Glory FC v North Queensland Fury | ME Bank Stadium | 8:00PM |
| Sat 7 Aug 2010 | Sydney FC v Melbourne Victory FC | Sydney Football Stadium | 7:30PM |
| Sun 8 Aug 2010 | Gold Coast United v Brisbane Roar FC | Skilled Park | 3:00PM |
Round 2
| Date | Venue | Time | |
| Fri 13 Aug 2010 | Wellington Phoenix FC v Gold Coast United | Westpac Stadium | 7:30PM |
| Fri 13 Aug 2010 | Newcastle Jets FC v Melbourne Heart | Energy Australia Stadium | 8:00PM |
| Sat 14 Aug 2010 | North Queensland Fury v Sydney FC | Dairy Farmers Stadium | 5:15PM |
| Sat 14 Aug 2010 | Melbourne Victory FC v North Queensland Fury | AAMI Park | 7:30PM |
| Sun 15 Aug 2010 | Central Coast Mariners FC v Adelaide United FC | Bluetongue Stadium | 3:00PM |
Round 3
| Date | Venue | Time | |
| Fri 20 Aug 2010 | Adelaide United FC v Melbourne Heart | Hindmarsh Stadium | 7:30PM |
| Sat 21 Aug 2010 | Perth Glory FC v Newcastle Jets FC | ME Bank Stadium | 3:15PM |
| Sat 21 Aug 2010 | Brisbane Roar FC v Sydney FC | Suncorp Stadium | 7:30PM |
| Sun 22 Aug 2010 | Wellington Phoenix FC v Central Coast Mariners FC | Westpac Stadium | 3:00PM |
| Sun 22 Aug 2010 | Melbourne Victory FC v North Queensland Fury | AAMI Park | 3:00PM |
Round 4
| Date | Venue | Time | |
| Fri 27 Aug 2010 | Brisbane Roar FC v Wellington Phoenix FC | Suncorp Stadium | 8:00PM |
| Sat 28 Aug 2010 | North Queensland Fury v Adelaide United FC | Dairy Farmers Stadium | 5:15PM |
| Sat 28 Aug 2010 | Sydney FC v Central Coast Mariners FC | Sydney Football Stadium | 7:30PM |
| Sun 29 Aug 2010 | Gold Coast United v Melbourne Victory FC | Skilled Park | 3:00PM |
| Sun 29 Aug 2010 | Melbourne Heart v Perth Glory FC | AAMI Park | 5:00PM |
Round 5
| Date | Venue | Time | |
| Fri 3 Sep 2010 | Central Coast Mariners FC v Melbourne Victory FC | Bluetongue Stadium | 7:00PM |
| Sat 4 Sep 2010 | Melbourne Heart v North Queensland Fury | AAMI Park | 5:15PM |
| Sat 4 Sep 2010 | Sydney FC v Adelaide United FC | Sydney Football Stadium | 7:30PM |
| Sun 5 Sep 2010 | Newcastle Jets FC v Brisbane Roar FC | Sydney Football Stadium | 3:00PM |
| Sun 5 Sep 2010 | Perth Glory FC v Sydney FC | ME Bank Stadium | 3:00PM |
Round 6
| Date | Venue | Time | |
| Fri 10 Sep 2010 | Central Coast Mariners FC v Melbourne Heart | Bluetongue Stadium | 8:00PM |
| Sat 11 Sep 2010 | Wellington Phoenix FC v Sydney FC | Westpac Stadium | 7:15PM |
| Sat 11 Sep 2010 | Adelaide United FC v Newcastle Jets FC | Sydney Football Stadium | 7:30PM |
| Sun 12 Sep 2010 | Melbourne Victory FC v Brisbane Roar FC | AAMI Park | 3:00PM |
| Sun 12 Sep 2010 | Perth Glory FC v Gold Coast United | ME Bank Stadium | 3:00PM |
| Wed 15 Sep 2010 | Melbourne Victory FC v Wellington Phoenix FC | AAMI Park | 7:30PM |
Round 7
| Date | Venue | Time | |
| Fri 17 Sep 2010 | Newcastle Jets FC v Perth Glory FC | Energy Australia Stadium | 8:00PM |
| Sat 18 Sep 2010 | North Queensland Fury v Melbourne Victory FC | Dairy Farmers Stadium | 5:14PM |
| Sat 18 Sep 2010 | Brisbane Roar FC v Adelaide United FC | Sydney Football Stadium | 7:30PM |
| Sun 19 Sep 2010 | Melbourne Heart v Wellington Phoenix FC | AAMI Park | 3:00PM |
| Sun 19 Sep 2010 | Gold Coast United v Central Coast Mariners FC | Skilled Park | 5:00PM |
| Wed 22 Sep 2010 | Gold Coast United v Newcastle Jets FC | Sydney Football Stadium | 7:30PM |
Round 8
| Date | Venue | Time | |
| Fri 24 Sep 2010 | Wellington Phoenix FC v North Queensland Fury | Westpac Stadium | 7:30PM |
| Fri 24 Sep 2010 | Adelaide United FC v Perth Glory FC | Hindmarsh Stadium | 7:30PM |
| Sat 25 Sep 2010 | Brisbane Roar FC v Melbourne Heart | Suncorp Stadium | 5:15PM |
| Sat 25 Sep 2010 | Newcastle Jets FC v Melbourne Victory FC | Energy Australia Stadium | 7:30PM |
| Sun 26 Sep 2010 | Sydney FC v Gold Coast United | Sydney Football Stadium | 3:00PM |
| Wed 29 Sep 2010 | Sydney FC v Newcastle Jets FC | Sydney Football Stadium | 7:30PM |
Round 9
| Date | Venue | Time | |
| Fri 1 Oct 2010 | Gold Coast United v Wellington Phoenix FC | Skilled Park | 8:00PM |
| Sat 2 Oct 2010 | Central Coast Mariners FC v North Queensland Fury | Bluetongue Stadium | 5:15PM |
| Sat 2 Oct 2010 | Melbourne Heart v Melbourne Victory FC | AAMI Park | 7:29PM |
| Sun 3 Oct 2010 | Perth Glory FC v Brisbane Roar FC | ME Bank Stadium | 5:00PM |
| Mon 4 Oct 2010 | Sydney FC v Adelaide United FC | Sydney Football Stadium | 5:00PM |
Round 10
| Date | Venue | Time | |
| Fri 15 Oct 2010 | North Queensland Fury v Perth Glory FC | Dairy Farmers Stadium | 7:30PM |
| Sat 16 Oct 2010 | Melbourne Victory FC v Sydney FC | Etihad Stadium | 7:00PM |
| Sat 16 Oct 2010 | Brisbane Roar FC v Newcastle Jets FC | Suncorp Stadium | 8:15PM |
| Sun 17 Oct 2010 | Wellington Phoenix FC v Melbourne Heart | Westpac Stadium | 5:00PM |
| Sun 17 Oct 2010 | Gold Coast United v Adelaide United FC | Skilled Park | 4:00PM |
| Wed 20 Oct 2010 | Brisbane Roar FC v Central Coast Mariners FC | Suncorp Stadium | 7:00PM |
Round 11
| Date | Venue | Time | |
| Fri 22 Oct 2010 | Adelaide United FC v Wellington Phoenix FC | Hindmarsh Stadium | 7:30PM |
| Sat 23 Oct 2010 | Melbourne Heart v Gold Coast United | AAMI Park | 7:00PM |
| Sat 23 Oct 2010 | Brisbane Roar FC v Melbourne Victory FC | Suncorp Stadium | 8:15PM |
| Sun 24 Oct 2010 | Newcastle Jets FC v North Queensland Fury | Energy Australia Stadium | 4:00PM |
Round 12
| Date | Venue | Time | |
| Sat 30 Oct 2010 | Central Coast Mariners FC v North Queensland Fury | Sydney Football Stadium | 3:45PM |
| Sat 30 Oct 2010 | Sydney FC v Brisbane Roar FC | Sydney Football Stadium | 6:00PM |
| Sat 30 Oct 2010 | Melbourne Victory FC v Adelaide United FC | Etihad Stadium | 8:15PM |
| Sun 31 Oct 2010 | Newcastle Jets FC v Melbourne Heart | Energy Australia Stadium | 3:00PM |
| Sun 31 Oct 2010 | North Queensland Fury v Gold Coast United | Dairy Farmers Stadium | 5:00PM |
| Wed 3 Nov 2010 | Wellington Phoenix FC v Brisbane Roar FC | Westpac Stadium | 7:30PM |
| Wed 3 Nov 2010 | Perth Glory FC v Melbourne Heart | ME Bank Stadium | 7:00PM |
Round 13
| Date | Venue | Time | |
| Fri 5 Nov 2010 | North Queensland Fury v Central Coast Mariners FC | Sydney Football Stadium | 7:30PM |
| Sat 6 Nov 2010 | Melbourne Victory FC v Gold Coast United | Sydney Football Stadium | 7:00PM |
| Sat 6 Nov 2010 | Brisbane Roar FC v Adelaide United FC | Sydney Football Stadium | 8:15PM |
| Sun 7 Nov 2010 | Sydney FC v Newcastle Jets FC | Sydney Football Stadium | 5:00PM |
| Sun 7 Nov 2010 | Perth Glory FC v Wellington Phoenix FC | ME Bank Stadium | 4:00PM |
| Wed 10 Nov 2010 | Adelaide United FC v Perth Glory FC | Hindmarsh Stadium | 6:30PM |
| Wed 10 Nov 2010 | North Queensland Fury v Melbourne Heart | Dairy Farmers Stadium | 8:00PM |
Round 14
| Date | Venue | Time | |
| Fri 12 Nov 2010 | Gold Coast United v Sydney FC | Skilled Park | 7:30PM |
| Sat 13 Nov 2010 | Wellington Phoenix FC v Central Coast Mariners FC | Westpac Stadium | 7:30PM |
| Sat 13 Nov 2010 | Newcastle Jets FC v Adelaide United FC | Energy Australia Stadium | 7:45PM |
| Sun 14 Nov 2010 | Melbourne Heart v Brisbane Roar FC | AAMI Park | 5:00PM |
| Sun 14 Nov 2010 | Perth Glory FC v Melbourne Victory FC | ME Bank Stadium | 4:00PM |
| Wed 17 Nov 2010 | Newcastle Jets FC v Brisbane Roar FC | Energy Australia Stadium | 7:30PM |
| Thu 18 Nov 2010 | Melbourne Victory FC v Central Coast Mariners FC | AAMI Park | 7:30PM |
Round 15
| Date | Venue | Time | |
| Fri 19 Nov 2010 | Melbourne Heart v Adelaide United FC | AAMI Park | 8:00PM |
| Sat 20 Nov 2010 | Newcastle Jets FC v Wellington Phoenix FC | Energy Australia Stadium | 7:00PM |
| Sat 20 Nov 2010 | Brisbane Roar FC v North Queensland Fury | Suncorp Stadium | 8:15PM |
| Sun 21 Nov 2010 | Sydney FC v Perth Glory FC | Sydney Football Stadium | 3:00PM |
| Sun 21 Nov 2010 | Central Coast Mariners FC v Gold Coast United | Bluetongue Stadium | 5:00PM |
| Wed 24 Nov 2010 | Wellington Phoenix FC v Melbourne Heart | Westpac Stadium | 7:30PM |
| Wed 24 Nov 2010 | Central Coast Mariners FC v Brisbane Roar FC | Bluetongue Stadium | 7:30PM |
Round 16
| Date | Venue | Time | |
| Fri 26 Nov 2010 | Adelaide United FC v Gold Coast United | Hindmarsh Stadium | 7:30PM |
| Sat 27 Nov 2010 | Wellington Phoenix FC v Melbourne Heart | Westpac Stadium | 6:00PM |
| Sat 27 Nov 2010 | Newcastle Jets FC v Central Coast Mariners FC | Energy Australia Stadium | 6:00PM |
| Sat 27 Nov 2010 | Melbourne Heart v Sydney FC | AAMI Park | 8:15PM |
| Sun 28 Nov 2010 | North Queensland Fury v Perth Glory FC | Dairy Farmers Stadium | 5:00PM |
| Wed 1 Dec 2010 | Sydney FC v Wellington Phoenix FC | Sydney Football Stadium | 7:00PM |
| Wed 1 Dec 2010 | Gold Coast United v North Queensland Fury | Skilled Park | 8:00PM |
Round 17
| Date | Venue | Time | |
| Wed 8 Dec 2010 | Melbourne Heart v Newcastle Jets FC | AAMI Park | 7:00PM |
| Sat 4 Dec 2010 | Central Coast Mariners FC v Sydney FC | Bluetongue Stadium | 7:00PM |
| Sat 4 Dec 2010 | North Queensland Fury v Newcastle Jets FC | Dairy Farmers Stadium | 8:15PM |
| Sun 5 Dec 2010 | Wellington Phoenix FC v Adelaide United FC | Westpac Stadium | 5:00PM |
| Sun 5 Dec 2010 | Gold Coast United v Melbourne Heart | Skilled Park | 4:00PM |
| Wed 8 Dec 2010 | Brisbane Roar FC v Perth Glory FC | Suncorp Stadium | 8:00PM |
Round 18
| Date | Venue | Time | |
| Fri 10 Dec 2010 | Adelaide United FC v North Queensland Fury | Hindmarsh Stadium | 7:30PM |
| Sat 11 Dec 2010 | Melbourne Heart v Melbourne Victory FC | AAMI Park | 7:00PM |
| Sat 11 Dec 2010 | Gold Coast United v Wellington Phoenix FC | Skilled Park | 8:15PM |
| Sun 12 Dec 2010 | Sydney FC v Brisbane Roar FC | Sydney Football Stadium | 5:00PM |
| Sun 12 Dec 2010 | Perth Glory FC v Central Coast Mariners FC | ME Bank Stadium | 5:00PM |
| Wed 15 Dec 2010 | Newcastle Jets FC v Gold Coast United | Energy Australia Stadium | 7:00PM |
| Wed 15 Dec 2010 | North Queensland Fury v Sydney FC | Dairy Farmers Stadium | 8:00PM |
Round 19
| Date | Venue | Time | |
| Fri 17 Dec 2010 | Adelaide United FC v Melbourne Heart | Hindmarsh Stadium | 7:30PM |
| Sat 18 Dec 2010 | Wellington Phoenix FC v Newcastle Jets FC | AMI Stadium | 7:00PM |
| Sat 18 Dec 2010 | Melbourne Victory FC v Perth Glory FC | AAMI Park | 7:00PM |
| Sat 18 Dec 2010 | North Queensland Fury v Brisbane Roar FC | Dairy Farmers Stadium | 8:15PM |
| Sun 19 Dec 2010 | Gold Coast United v Central Coast Mariners FC | Skilled Park | 4:00PM |
| Wed 22 Dec 2010 | Central Coast Mariners FC v Newcastle Jets FC | Bluetongue Stadium | 7:30PM |
| Wed 22 Dec 2010 | Perth Glory FC v Adelaide United FC | ME Bank Stadium | 7:00PM |
Round 20
| Date | Venue | Time | |
| Thu 23 Dec 2010 | Sydney FC v Melbourne Heart | Sydney Football Stadium | 7:00PM |
| Sun 26 Dec 2010 | Central Coast Mariners FC v Adelaide United FC | Bluetongue Stadium | 5:00PM |
| Sun 26 Dec 2010 | Brisbane Roar FC v Gold Coast United | Suncorp Stadium | 8:15PM |
| Mon 27 Dec 2010 | North Queensland Fury v Wellington Phoenix FC | Dairy Farmers Stadium | 7:15PM |
| Wed 29 Dec 2010 | Adelaide United FC v Sydney FC | Adelaide Oval | 4:00PM |
Round 21
| Date | Venue | Time | |
| Fri 31 Dec 2010 | Central Coast Mariners FC v Melbourne Victory FC | Bluetongue Stadium | 6:00PM |
| Sun 2 Jan 2011 | Melbourne Heart v North Queensland Fury | AAMI Park | 5:00PM |
| Sun 2 Jan 2011 | Adelaide United FC v Brisbane Roar FC | Hindmarsh Stadium | 6:30PM |
| Mon 3 Jan 2011 | Newcastle Jets FC v Sydney FC | Energy Australia Stadium | 5:00PM |
| Wed 5 Jan 2011 | Wellington Phoenix FC v Melbourne Victory FC | Westpac Stadium | 7:30PM |
Round 22
| Date | Venue | Time | |
| Fri 7 Jan 2011 | Brisbane Roar FC v Perth Glory FC | Suncorp Stadium | 7:30PM |
| Sat 8 Jan 2011 | Sydney FC v Gold Coast United | Sydney Football Stadium | 7:00PM |
| Sat 8 Jan 2011 | North Queensland Fury v Newcastle Jets FC | Dairy Farmers Stadium | 8:15PM |
| Sun 9 Jan 2011 | Melbourne Victory FC v Adelaide United FC | Etihad Stadium | 3:00PM |
| Sun 9 Jan 2011 | Central Coast Mariners FC v Brisbane Roar FC | Bluetongue Stadium | 5:00PM |
| Wed 12 Jan 2011 | Central Coast Mariners FC v Adelaide United FC | Bluetongue Stadium | 6:30PM |
Round 23
| Date | Venue | Time | |
| Fri 14 Jan 2011 | Gold Coast United v North Queensland Fury | Skilled Park | 7:30PM |
| Sat 15 Jan 2011 | Sydney FC v Melbourne Victory FC | Sydney Football Stadium | 7:30PM |
| Sun 16 Jan 2011 | Newcastle Jets FC v Central Coast Mariners FC | Energy Australia Stadium | 5:00PM |
| Sun 16 Jan 2011 | Brisbane Roar FC v Wellington Phoenix FC | Suncorp Stadium | 6:00PM |
| Wed 19 Jan 2011 | Melbourne Heart v Gold Coast United | AAMI Park | 8:00PM |
| Wed 19 Jan 2011 | Perth Glory FC v Central Coast Mariners FC | ME Bank Stadium | 7:00PM |
Round 24
| Date | Venue | Time | |
| Fri 21 Jan 2011 | Adelaide United FC v North Queensland Fury | Hindmarsh Stadium | 7:30PM |
| Sat 22 Jan 2011 | Melbourne Victory FC v Melbourne Heart | Etihad Stadium | 7:00PM |
| Sat 22 Jan 2011 | Gold Coast United v Melbourne Victory FC | Skilled Park | 8:15PM |
| Sun 23 Jan 2011 | Wellington Phoenix FC v Perth Glory FC | Westpac Stadium | 5:00PM |
| Sun 23 Jan 2011 | Central Coast Mariners FC v Sydney FC | Bluetongue Stadium | 5:00PM |
| Wed 26 Jan 2011 | North Queensland Fury v Melbourne Victory FC | Dairy Farmers Stadium | 7:00PM |
Round 25
| Date | Venue | Time | |
| Fri 28 Jan 2011 | Brisbane Roar FC v Melbourne Heart | Suncorp Stadium | 7:30PM |
| Sat 29 Jan 2011 | Adelaide United FC v Central Coast Mariners FC | Hindmarsh Stadium | 7:00PM |
| Sat 29 Jan 2011 | Perth Glory FC v Sydney FC | ME Bank Stadium | 6:45PM |
| Sun 30 Jan 2011 | Wellington Phoenix FC v Newcastle Jets FC | Westpac Stadium | 5:00PM |
| Sun 30 Jan 2011 | Melbourne Victory FC v Gold Coast United | AAMI Park | 5:00PM |
| Wed 2 Feb 2011 | Melbourne Victory FC v Newcastle Jets FC | AAMI Park | 7:00PM |
| Wed 2 Feb 2011 | Gold Coast United v Adelaide United FC | Skilled Park | 8:00PM |
Round 26
| Date | Venue | Time | |
| Fri 4 Feb 2011 | Melbourne Heart v Central Coast Mariners FC | AAMI Park | 8:00PM |
| Sat 5 Feb 2011 | Adelaide United FC v Wellington Phoenix FC | Hindmarsh Stadium | 6:30PM |
| Sat 5 Feb 2011 | North Queensland Fury v Brisbane Roar FC | Dairy Farmers Stadium | 8:15PM |
| Sun 6 Feb 2011 | Newcastle Jets FC v Sydney FC | Energy Australia Stadium | 5:00PM |
| Sun 6 Feb 2011 | Perth Glory FC v Gold Coast United | ME Bank Stadium | 5:00PM |
| Wed 9 Feb 2011 | Sydney FC v Wellington Phoenix FC | Sydney Football Stadium | 7:00PM |
| Thu 10 Feb 2011 | Newcastle Jets FC v Perth Glory FC | Energy Australia Stadium | 7:30PM |
Round 27
| Date | Venue | Time | |
| Fri 11 Feb 2011 | Adelaide United FC v Melbourne Victory FC | Adelaide Oval | 7:30PM |
| Sat 12 Feb 2011 | Melbourne Heart v Perth Glory FC | AAMI Park | 7:00PM |
| Sat 12 Feb 2011 | Brisbane Roar FC v Gold Coast United | Suncorp Stadium | 8:15PM |
| Sun 13 Feb 2011 | Wellington Phoenix FC v North Queensland Fury | Westpac Stadium | 5:00PM |
| Sun 13 Feb 2011 | Central Coast Mariners FC v Newcastle Jets FC | Bluetongue Stadium | 5:00PM |